Thrombophilia is defined as predisposition of the organism to thrombosis development. There are acquired and inherited thrombophilia; both of them are considered as risk factors for arterial, venous and microcirculatory thrombosis. Kidney disease in patients with a genetic polymorphism of coagulation factors are manifested as renal vein and artery thrombosis, and thrombosis of renal microvasculature - thrombotic microangiopathy. Combination of thrombotic microangiopathy and chronic glomerulonephritis further the disease progression due to progressive nephrosclerosis.

Keywords: thrombotic microangiopathy, С677Т MTHFR gene polymorphism, 4G/5G PAI gene polymorphism, thrombophylia, nephrosclerosis